Some biochemical markers and expression of indoleamine-2, 3-dioxygenase in Egyptian patients with chronic Hepatitis C.

Indoleamine 2,3-dioxygenase expression and activity in patients with hepatitis C virus-induced liver cirrhosis

Indoleamine 2,3-dioxygenase (IDO) is an immunoregulatory enzyme. It plays a key role in various malignancies, infection and autoimmune diseases. IDO induces immunosuppression through the depletion of tryptophan and its downstream metabolites. Hepatitis C virus (HCV) has infected more than 12 million individuals in Pakistan. The aim of the present study was to assess the expression and activity ...

IDO 2 ( indoleamine 2 , 3 - dioxygenase 2 )

Evaluation of Fibrosis Progression by Noninvasive Biochemical Markers in Egyptian Patients with Chronic Hepatitis B Euroasian

Hepatitis B virus (HBV) and hepatitis C virus (HCV), the major causes of chronic liver diseases, are responsible for hepatic inflammation, liver fibrosis, liver cirrhosis and hepatocellular carcinoma (HCC).1-3 Several recent progresses have been accomplished in the diagnosis and treatment of chronic liver diseases. However, it seems that conventional biochemical and serological tests are of lim...

Upregulation of indoleamine 2,3-dioxygenase in hepatitis C virus infection.

Indoleamine 2,3-dioxygenase (IDO) is induced by proinflammatory cytokines and by CTLA-4-expressing T cells and constitutes an important mediator of peripheral immune tolerance. In chronic hepatitis C, we found upregulation of IDO expression in the liver and an increased serum kynurenine/tryptophan ratio (a reflection of IDO activity). Huh7 cells supporting hepatitis C virus (HCV) replication ex...

Apelin Serum Level in Egyptian Patients with Chronic Hepatitis C

OBJECTIVE Highlighting the apelin system would present a new therapeutic target for liver disease. Apelin; endogenous ligand for the orphan receptor APJ, was recently suggested to be associated with fibrosis progression and cirrhosis in addition to insulin resistance (IR) and inflammation. The present study was conducted to evaluate blood apelin level changes among 73 chronic hepatitis C (CHC) ...